Cleerly

Cleerly is a US cardiac-imaging AI company founded in 2016 and headquartered in Denver, Colorado. It targets underdiagnosis of coronary artery disease, since standard CT angiography reports often describe plaque only qualitatively rather than measuring how much disease is present.

Its web-based platform analyzes coronary CT angiography scans to quantify plaque burden, characterize plaque composition and estimate ischemia risk, then stages patients into a standardized disease-severity framework used to guide treatment and follow-up. Modules include Plaque Analysis, ISCHEMIA and COMPARE for tracking change over time. Cleerly works with cardiologists and health systems and has recently gained commercial insurance coverage in the US.

1. Plaque Analysis: quantifies total coronary plaque burden from CT angiography.

2. ISCHEMIA module: estimates blood-flow-limiting risk without invasive testing.

3. COMPARE: tracks plaque progression or regression across follow-up scans.

4. Standardized staging: classifies disease severity to guide treatment decisions.

5. Web-based delivery: integrates results into cardiologists' existing imaging workflow.

6. Payer coverage: reimbursed by select US commercial insurers as of 2026.